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Uric Acid as a Redox Switch in Gout: Linking Xanthine Oxidoreductase-Derived ROS, NLRP3 Inflammasome Activation and Emerging Ferroptotic Mechanisms

The discussion that follows is applicable to xenobiotics in general (including drugs) and to some extent to endogenous compounds

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When there is excess ROS and a decline in the endogenous antioxidant system, such as in inflammatory skin diseases, ingestion or topical application of antioxidant molecules could theoretically be indicated [32,33]